IFT-81 and IFT-74 are required for intraflagellar transport inC. elegans
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چکیده
منابع مشابه
Intraflagellar transport (IFT) cargo
Intraflagellar transport (IFT) is the bidirectional movement of multisubunit protein particles along axonemal microtubules and is required for assembly and maintenance of eukaryotic flagella and cilia. One posited role of IFT is to transport flagellar precursors to the flagellar tip for assembly. Here, we examine radial spokes, axonemal subunits consisting of 22 polypeptides, as potential cargo...
متن کاملChlamydomonas Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in Caenorhabditis elegans Sensory Neurons
We previously described a kinesin-dependent movement of particles in the flagella of Chlamydomonas reinhardtii called intraflagellar transport (IFT) (Kozminski, K.G., K.A. Johnson, P. Forscher, and J.L. Rosenbaum. 1993. Proc. Natl. Acad. Sci. USA. 90:5519-5523). When IFT is inhibited by inactivation of a kinesin, FLA10, in the temperature-sensitive mutant, fla10, existing flagella resorb and ne...
متن کاملIntraflagellar transport (IFT) during assembly and disassembly of Chlamydomonas flagella
Intraflagellar transport (IFT) of particles along flagellar microtubules is required for the assembly and maintenance of eukaryotic flagella and cilia. In Chlamydomonas, anterograde and retrograde particles viewed by light microscopy average 0.12-microm and 0.06-microm diameter, respectively. Examination of IFT particle structure in growing flagella by electron microscopy revealed similar size ...
متن کاملIntraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body
Due to a printer error, Figure 9 was mislabeled. The bottom-center panel should have read " HA-RSP3 " instead of " Acetylated tubulin. " The corrected figure appears below. ntraflagellar transport (IFT) is the bidirectional movement of multisubunit protein particles along axonemal micro-tubules and is required for assembly and maintenance of eukaryotic flagella and cilia. One posited role of IF...
متن کاملIntraflagellar Transport (IFT) Protein IFT25 Is a Phosphoprotein Component of IFT Complex B and Physically Interacts with IFT27 in Chlamydomonas
BACKGROUND Intraflagellar transport (IFT) is the bidirectional movement of IFT particles between the cell body and the distal tip of a flagellum. Organized into complexes A and B, IFT particles are composed of at least 18 proteins. The function of IFT proteins in flagellar assembly has been extensively investigated. However, much less is known about the molecular mechanism of how IFT is regulat...
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ژورنال
عنوان ژورنال: Genes to Cells
سال: 2007
ISSN: 1356-9597
DOI: 10.1111/j.1365-2443.2007.01076.x